Ausgewählte Veröffentlichungen (ab 2001 nach Erscheinungsdatum):

TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations.

Joussen AM, Doehmen S, Le ML, Koizumi K, Radetzky S, Krohne TU, Poulaki V, Semkova I, Kociok N. Mol Vis. 2009 Jul 25;15:1418-28.PMID: 19641635 

ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization.

Kociok N, Radetzky S, Krohne TU, Gavranic C, Liang Y, Semkova I, Joussen AM. Exp Eye Res. 2009 Oct;89(4):503-10. Epub 2009 May 29.PMID: 19482023

Shifting of the proliferative vitreoretinopathy milieu after tamponade with heavy silicone oil in eyes prone to proliferative vitreoretinopathy and bleeding.

Joussen AM, Lux A, Kirchhof B. Br J Ophthalmol. 2009 Jan;93(1):128-9. PMID: 19098052

A cleaning solution for silicone intraocular lenses: "sticky silicone oil".

Liang Y, Kociok N, Leszczuk M, Hiebl W, Theisinger B, Lux A, Joussen AM.

Br J Ophthalmol. 2008 Nov;92(11):1522-7. Epub 2008 Aug 26.PMID: 18728053

The concept of heavy tamponades-chances and limitations.

Joussen AM, Wong D. Graefes Arch Clin Exp Ophthalmol. 2008 Sep;246(9):1217-24. Epub 2008 Jun 11. Review.PMID: 18546009

Pneumatic retinopexy by evaporation of fluorocarbon liquids: in vitro and in vivo results.

Mackiewicz J, Mühling B, Hiebl W, Meinert H, Kociok N, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2008 Jan;246(1):69-79. Epub 2007 Oct 10.PMID: 17926057

Modulation of hypoxia-induced neovascularization by JSM6427, an integrin alpha5beta1 inhibiting molecule.

Maier AK, Kociok N, Zahn G, Vossmeyer D, Stragies R, Muether PS, Joussen AM.

Curr Eye Res. 2007 Sep;32(9):801-12.PMID: 17882713

The role of integrin alpha5beta1 in the regulation of corneal neovascularization.

Muether PS, Dell S, Kociok N, Zahn G, Stragies R, Vossmeyer D, Joussen AM.

Exp Eye Res. 2007 Sep;85(3):356-65. Epub 2007 Jun 15.PMID: 17659277

Triamcinolone versus inner-limiting membrane peeling in persistent diabetic macular edema (TIME study): design issues and implications.

Joussen AM, Weiss C, Bauer D, Hilgers RD; TIME Study group. Graefes Arch Clin Exp Ophthalmol. 2007 Dec;245(12):1781-7. Epub 2007 Jul 26.PMID: 17653751

Autologous translocation of the choroid and RPE in age-related macular degeneration: 1-year follow-up in 30 patients and recommendations for patient selection.

Heussen FM, Fawzy NF, Joeres S, Lux A, Maaijwee K, Meurs JC, Kirchhof B, Joussen AM.

Eye (Lond). 2008 Jun;22(6):799-807. Epub 2007 Jul 20.PMID: 17641681

Retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: long-term results.

Maaijwee K, Heimann H, Missotten T, Mulder P, Joussen A, van Meurs J. Graefes Arch Clin Exp Ophthalmol. 2007 Nov;245(11):1681-9. Epub 2007 Jun 12.PMID: 17562066

Non-responders to bevacizumab (Avastin) therapy of choroidal neovascular lesions.

Lux A, Llacer H, Heussen FM, Joussen AM. Br J Ophthalmol. 2007 Oct;91(10):1318-22. Epub 2007 May 30.PMID: 17537784

Is significant relevant? Validity and patient benefit of randomized controlled clinical trials on age-related macular degeneration.

Joussen AM, Lehmacher W, Hilgers RD, Kirchhof B. Surv Ophthalmol. 2007 May-Jun;52(3):266-78. Review.PMID: 17472802

Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): design issues and implications.

Joussen AM, Kirchhof B, Schrage N, Ocklenburg C, Hilgers RD; HSO Study Group. Acta Ophthalmol Scand. 2007 Sep;85(6):623-30. Epub 2007 Apr 4.PMID: 17408389

In vivo retinal tolerance of various heavy silicone oils.

Mackiewicz J, Mühling B, Hiebl W, Meinert H, Maaijwee K, Kociok N, Lüke C, Zagorski Z, Kirchhof B, Joussen AM. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1873-83.PMID: 17389523

Optical coherence tomography on autologous translocation of choroid and retinal pigment epithelium in age-related macular degeneration.

Joeres S, Llacer H, Heussen FM, Weiss C, Kirchhof B, Joussen AM. Eye (Lond). 2008 Jun;22(6):782-9. Epub 2007 Mar 2.PMID: 17332766

Autologous translocation of the choroid and retinal pigment epithelium in patients with geographic atrophy.

Joussen AM, Joeres S, Fawzy N, Heussen FM, Llacer H, van Meurs JC, Kirchhof B. Ophthalmology. 2007 Mar;114(3):551-60.PMID: 17324697

Benefits and limitations in vitreoretinal surgery for proliferative diabetic retinopathy and macular edema.

Joussen AM, Joeres S. Dev Ophthalmol. 2007;39:69-87. Review.PMID: 17245079

Pathophysiology of diabetic macular edema.

Joussen AM, Smyth N, Niessen C. Dev Ophthalmol. 2007;39:1-12. Review.PMID: 17245075

Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice.

Kociok N, Radetzky S, Krohne TU, Gavranic C, Joussen AM. Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5057-65.PMID: 17065527

Effect of gravity in long-term vitreous tamponade: in vivo investigation using perfluorocarbon liquids and semi-fluorinated alkanes.

Mackiewicz J, Maaijwee K, Lüke C, Kociok N, Hiebl W, Meinert H, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):665-75. Epub 2006 Oct 11.PMID: 17033791

Histological evidence for revascularisation of an autologous retinal pigment epithelium--choroid graft in the pig.

Maaijwee KJ, van Meurs JC, Kirchhof B, Mooij CM, Fischer JH, Mackiewicz J, Kobuch K, Joussen AM. Br J Ophthalmol. 2007 Apr;91(4):546-50. Epub 2006 Sep 20.PMID: 16987900

Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization.

Shi X, Semkova I, Müther PS, Dell S, Kociok N, Joussen AM. Exp Eye Res. 2006 Dec;83(6):1325-34. Epub 2006 Sep 7.PMID: 16959248

Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration.

Joussen AM, Heussen FM, Joeres S, Llacer H, Prinz B, Rohrschneider K, Maaijwee KJ, van Meurs J, Kirchhof B. Am J Ophthalmol. 2006 Jul;142(1):17-30.PMID: 16815247

Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.

Semkova I, Fauser S, Lappas A, Smyth N, Kociok N, Kirchhof B, Paulsson M, Poulaki V, Joussen AM. FASEB J. 2006 Aug;20(10):1689-91. Epub 2006 Jun 28.PMID: 16807368

Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity.

Kociok N, Krohne TU, Poulaki V, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2007 Feb;245(2):258-66.PMID: 16741710

PVR as a complication of rhegmatogeneous retinal detachment: a solved problem?

Joeres S, Kirchhof B, Joussen AM. Br J Ophthalmol. 2006 Jun;90(6):796-7. No abstract available. PMID: 16714271

The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization.

Dell S, Peters S, Müther P, Kociok N, Joussen AM. Invest Ophthalmol Vis Sci. 2006 May;47(5):1928-37.PMID: 16639000

Varied expression of functionally important genes of RPE and choroid in the macula and in the periphery of normal human eyes.

Kociok N, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2007 Jan;245(1):101-13. Epub 2006 Apr 6.PMID: 16598467

Increased leukocyte-endothelial interactions in syndecan-1-deficient mice involve heparan sulfate-dependent and -independent steps.

Götte M, Bernfield M, Joussen AM. Curr Eye Res. 2005 Jun;30(6):417-22.PMID: 16020273

Influence on membrane-mediated cell activation by vesicles of silicone oil or perfluorohexyloctane.

Kociok N, Gavranic C, Kirchhof B, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2005 Apr;243(4):345-58. Epub 2004 Oct 27.PMID: 15864624

[Surgical treatment of diabetic retinopathy and maculopathy]

Joussen AM, Llacer H, Mazciewicz J, Kirchhof B. Ophthalmologe. 2004 Dec;101(12):1171-80. Review. German. PMID: 15592847

[Peripheral retinal degenerations--treatment recommendations]

Joussen AM, Kirchhof B. Ophthalmologe. 2004 Oct;101(10):1035-47; quiz 1048-9. German. PMID: 15365748

Insulin-like growth factor-I plays a pathogenetic role in diabetic retinopathy.

Poulaki V, Joussen AM, Mitsiades N, Mitsiades CS, Iliaki EF, Adamis AP. Am J Pathol. 2004 Aug;165(2):457-69.PMID: 15277220

A central role for inflammation in the pathogenesis of diabetic retinopathy.

Joussen AM, Poulaki V, Le ML, Koizumi K, Esser C, Janicki H, Schraermeyer U, Kociok N, Fauser S, Kirchhof B, Kern TS, Adamis AP. FASEB J. 2004 Sep;18(12):1450-2. Epub 2004 Jul 1.PMID: 15231732

Visual outcome of patients with macular edema after pars plana vitrectomy and indocyanine green-assisted peeling of the internal limiting membrane.

Radetzky S, Walter P, Fauser S, Koizumi K, Kirchhof B, Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2004 Apr;242(4):273-8. Epub 2004 Mar 23.PMID: 15042375

Activin a in the regulation of corneal neovascularization and vascular endothelial growth factor expression.

Poulaki V, Mitsiades N, Kruse FE, Radetzky S, Iliaki E, Kirchhof B, Joussen AM. Am J Pathol. 2004 Apr;164(4):1293-302.PMID: 15039217

Cell transplantation in age related macular degeneration: current concepts and future hopes.

Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2004 Jan;242(1):1-2. Epub 2003 Nov 14. PMID: 14745559

Contribution of TNF-alpha to leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis in vivo.

Koizumi K, Poulaki V, Doehmen S, Welsandt G, Radetzky S, Lappas A, Kociok N, Kirchhof B, Joussen AM. Invest Ophthalmol Vis Sci. 2003 May;44(5):2184-91.PMID: 12714660

VEGF-dependent conjunctivalization of the corneal surface.

Joussen AM, Poulaki V, Mitsiades N, Stechschulte SU, Kirchhof B, Dartt DA, Fong GH, Rudge J, Wiegand SJ, Yancopoulos GD, Adamis AP. Invest Ophthalmol Vis Sci. 2003 Jan;44(1):117-23.PMID: 12506063

Suppression of Fas-FasL-induced endothelial cell apoptosis prevents diabetic blood-retinal barrier breakdown in a model of streptozotocin-induced diabetes.

Joussen AM, Poulaki V, Mitsiades N, Cai WY, Suzuma I, Pak J, Ju ST, Rook SL, Esser P, Mitsiades CS, Kirchhof B, Adamis AP, Aiello LP. FASEB J. 2003 Jan;17(1):76-8. Epub 2002 Nov 15.PMID: 12475915

Angiostatin inhibits and regresses corneal neovascularization.

Ambati BK, Joussen AM, Ambati J, Moromizato Y, Guha C, Javaherian K, Gillies S, O'Reilly MS, Adamis AP. Arch Ophthalmol. 2002 Aug;120(8):1063-8.PMID: 12149060

Suppression of diabetic retinopathy with angiopoietin-1.

Joussen AM, Poulaki V, Tsujikawa A, Qin W, Qaum T, Xu Q, Moromizato Y, Bursell SE, Wiegand SJ, Rudge J, Ioffe E, Yancopoulos GD, Adamis AP. Am J Pathol. 2002 May;160(5):1683-93.PMID: 12000720

Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF.

Poulaki V, Qin W, Joussen AM, Hurlbut P, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. J Clin Invest. 2002 Mar;109(6):805-15.PMID: 11901189

Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.

Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Am J Pathol. 2002 Feb;160(2):501-9.PMID: 11839570

Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression.

Joussen AM, Poulaki V, Mitsiades N, Kirchhof B, Koizumi K, Döhmen S, Adamis AP. FASEB J. 2002 Mar;16(3):438-40. Epub 2002 Jan 30.PMID: 11821258

Vascular plasticity--the role of the angiopoietins in modulating ocular angiogenesis.

Joussen AM. Graefes Arch Clin Exp Ophthalmol. 2001 Dec;239(12):972-5. Review.PMID: 11820705

In vivo retinal gene expression in early diabetes.

Joussen AM, Huang S, Poulaki V, Camphausen K, Beecken WD, Kirchhof B, Adamis AP. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):3047-57.PMID: 11687554

[Diabetic maculopathy. Etiological mechanisms and possible treatment approaches]

Joussen AM, Lemmen KD, Kirchhof B. Ophthalmologe. 2001 Sep;98(9):908-18; quiz 919, 921. Review. German. No abstract available. PMID: 11594237

Inhibition of inflammatory corneal angiogenesis by TNP-470.

Joussen AM, Beecken WD, Moromizato Y, Schwartz A, Kirchhof B, Poulaki V. Invest Ophthalmol Vis Sci. 2001 Oct;42(11):2510-6.PMID: 11581191

VEGF-initiated blood-retinal barrier breakdown in early diabetes.

Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2408-13.PMID: 11527957